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Undergraduate education: I obtained first level degree in Biotechnologies 110/110 cum laude at the University of Padova in September 2004, working in purification and biochemical and immunological characterization of Fab fragments against a new invasin of Neisseria meningitides, under the supervision of Prof. E. Papini at the Department of Experimental Biomedical Science of the University of Padova.
I obtained specialistic degree in Industrial Biotecnologies curriculum Immunological Biotecnologies and Recombinant Proteins 110 /110 cum laude at the University of Padova in October 2006. I worked at my thesis Project in the Section of Oncology of the Department of Oncology and Surgical Sciences of the University of Padua, under the supervision of Dr. S. Indraccolo and Prof. A. Amadori. I studied interactions between Molt-3, a T-ALL cell line, and endothelial cells in a murine model of tumor dormancy to understand the biochemical events that may induce the activation of the Notch3 signalling pathway in tumour growth.
Statement of research interests: Cell migration in antigen-stimulated lymph nodes and the control of adaptive immune responses. We have recently found that the constitutive cell traffic in lymph nodes is perturbed when the lymph node is stimulated by migrating mature dendritic cells or certain adjuvants [Martin-Fontecha, 2004]. NK cells as well as CCR7? L-selective? T lymphocytes are efficiently recruited to stimulated LN whereas they are excluded from resting lymph nodes. Cytokines and other effector molecules, such as granzyme and perforin, produced by these recruited cells influence T cell priming and development of immune responses. We will use a variety of approaches to dissect the mechanisms responsible for the inducible pathway of cell migration in antigen-stimulated lymph nodes and explore the consequence of this perturbed migration on the extent and quality of effector and memory T cells generated.
Expectations from Integramm: I expect to spend the most part of my working time learning to do research, finding out new things and having freedom to pursue new areas. During the International Graduate Program in Molecular Medicine I hope to acquire strong skills in independent and effective thinking, critical analysis and problem-solving, that are required to develop a career in research, either at the academic or industrial level.
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