Goals: Our group is interested in understanding how signaling from antigen receptors, costimulatory molecules and cytokines determines lymphocyte fate. Our working hypothesis is that lymphocyte differentiation is a progressive process determined by the cumulative strength of stimulation (i.e. intensity and duration) resulting from the stochastic exposure of T cells to antigen presenting cells and cytokines.
Achievements: Definition of mechanisms of antigen capture, processing and presentation by B cells and DC.
Definition of mechanisms of TCR triggering and signal amplification by CD28.
Definition of hierarchical thresholds for T cell differentiation.
Definition of mechanisms that maintain short-term and long-term serological memory.