Marco E. Bianchi
Francesco Blasi
Daniele D'Ambrosio
Manuel Fresno
Antonio Lanzavecchia
Federico Major Jr.
Paola Panina-Bordignon
›› Ruggero Pardi
Anne Ridley
Federica Sallusto
Francisco Sanchez-Madrid
Marcus Thelen
Bart Vanhaesebroeck
Marketa Zvelebil
Ruggero Pardi
Affiliation: Vita-Salute San Raffaele University

Goals: Signaling role of adhesion receptors and the role played by the spatial-temporal regulation of integrin function in establishing and maintaining cell polarity during directional migration of leukocytes.

Achievements: Integrins as signal transducing units affecting the onset of genetic programs. Role of selected regions in integrin cytoplasmic domains in the control of the receptor’s endo-exocytic cyle and in ligand-supported migration.