Marco E. Bianchi
›› Francesco Blasi
Daniele D'Ambrosio
Manuel Fresno
Antonio Lanzavecchia
Federico Major Jr.
Paola Panina-Bordignon
Ruggero Pardi
Anne Ridley
Federica Sallusto
Francisco Sanchez-Madrid
Marcus Thelen
Bart Vanhaesebroeck
Marketa Zvelebil
Francesco Blasi
Affiliation: Vita-Salute San Raffaele University

Goals: Understanding the role of the urokinase receptor at the intersection between cell migration and cell proliferation.

Achievements: In the past we have first determined the molecular mechanism whereby uPA/uPAR induce a chemotactic response, by highlighting and identifying the existence of a chemotactic epitope in the uPAR molecule which is hidden in the absence of uPA: Subsequently we have identified in a G protein-coupled receptor (FPRL1, Formyl Peptide Receptor Like Protein-1) the trans-membrane ligand of the uPAR chemotactic epitope.