Marco E. Bianchi
Francesco Blasi
Daniele D'Ambrosio
Manuel Fresno
Antonio Lanzavecchia
Federico Major Jr.
Paola Panina-Bordignon
Ruggero Pardi
Anne Ridley
Federica Sallusto
›› Francisco Sanchez-Madrid
Marcus Thelen
Bart Vanhaesebroeck
Marketa Zvelebil
Francisco Sanchez-Madrid
Affiliation: Universidad Autonoma de Madrid

Goals: A first aim of our laboratory is to study the functional role of dynamic interactions among vascular endothelial adhesion molecules (ICAMs, VCAM-1, integrin/tetraspanin complexes), regulatory molecules (tyrosine kinase Syk), and cytoskeletal components (ERM proteins) that orchestrate leukocyte adhesion and transendothelial migration.

Achievements: Our laboratory has contributed in recent years to: 1) identification and establishment of cell surface receptors as markers for the two poles of a polarized migrating leukocyte; chemokine receptors at the leading edge, and adhesion receptors ICAMs at the uropod; 2) chemokines as the physiologic mediators of leukocyte polarization prior to cell migration; 3) membrane receptor-cytoskeletal interactions that drive cell polarity; chemokine receptor connection with the acto-myosin system, and adhesion molecules ICAMs, PSGL-1 and VCAM-1 interaction with ERM actin-binding proteins