Marco E. Bianchi
Francesco Blasi
Daniele D'Ambrosio
›› Manuel Fresno
Antonio Lanzavecchia
Federico Major Jr.
Paola Panina-Bordignon
Ruggero Pardi
Anne Ridley
Federica Sallusto
Francisco Sanchez-Madrid
Marcus Thelen
Bart Vanhaesebroeck
Marketa Zvelebil
Manuel Fresno
Affiliation: Universidad Autonoma de Madrid

Goals: Cyclooxigenases (COXs) mediate the synthesis of prostaglandins from arachidonate. COX-1 shows a constitutive expression in different cell types and is involved in the homeostatic function of prostaglandins. In contrast, COX-2 expression can be induced by a number of mitogenic, inflammatory, and pro-oncogenic stimuli and plays a key role in a variety of processes, including the onset of the inflammatory response, mitogenesis, angiogenesis, and tumor progression and

Achievements: Mice: COX-2-/- and other KO mice; Stable COX-2 and various prostaglandin synthetases inducible transfected T cell lines. Immunological assays. Signal transduction assays. Expression of adhesion molecules and adhesion to EC monolayers. Modulation by proinflammatory cytokines. Our lab has good animal and proteomics facilities.